Thematic meeting: Targeted Protein Degradation
This One-Day Thematic Meeting on « Targeted Protein Degradation: past, current and future strategies» organized by the Société de Chimie Thérapeutique (SCT) is at the frontier of developing new health technologies for the benefit of patients. This one-day symposium is a great opportunity for 8 European and US “Targeting Protein Degradation” experts from academy and industry to share recent results from their research.
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Date & Location
- Thursday, 30th May 2024. 9 am - 5 pm
- Sanofi Gentilly Campus, 80 rue Raspail, 94250 Gentilly, France
- Programme
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9h00 - 09h30 Welcome & Coffee
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09h30 - 10h15 Prof. Daniel Nomura (Berkeley)
Reimagining Druggability using Chemoproteomic Platforms
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10h15 - 10h45 Dr. Martin Schroeder (Novartis)
Novel and reversible DCAF1 ligands expand the TPD-toolbox
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10H45 - 11h15 Coffee break
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11h15 - 12h00 Prof. Nicolas Thomä (Lausanne University)
How to drug and degrade oncogenic transcription factors
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12h00 - 12h30 Dr. Ester Morreale (Crick Institute)
Enabling targeted protein degradation in bacteria
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12h30 - 12h45 Promega presentation
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12h45 - 14h00 Lunch & Exposition
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14H00 -14h45 Prof. Ivan Dikic (Max Planck Institut of Bio)
Discovery of novel molecular glues and anti-microbial PROTACs
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14h45 - 15h15 Dr. Manfred Koegl (Boehringer Ingelheim)
Breaking Bad Proteins: Targeted Protein Degradation in Oncology
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15h15 -15h35 Coffee Break
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15h35 - 16h05 Dr. Samir Jegham (Sanofi)
Opportunities And Challenges: Case study of the SAR444656 the 1st orally bioavailable clinical IRAK4 Degrader for the treatment of autoimmune diseases.
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16h05 - 16h35 Dr Kirsten McAulay (Dundee University, CETP)
PROTAC Design for Oncology Targets – an Industry-Academia Collaboration
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16h35 - 17h05 Prof. Anne-Sophie Voisin-Chiret (Caen university)
Targeted protein degradation, a groundbreaking strategy for drug discovery. Application to the degradation of the Mcl-1 protein as a promising route for developing novel cancer therapeutics.
- Organizing committee:
- Y. Foricher (SANOFI & SCT)
- G. Laconde (OXELTIS & SCT)
- JY Ortholand (Edelris & SCT)
- M Duca (CNRS & SCT)
- Sponsors